Pengcheng Fu Systems Biology and Synthetic Biology

The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.

17477.19 RUR

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Chiarabelli Cristiano Chemical Synthetic Biology

Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.

15555.61 RUR

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Lodhi Huma M. Elements of Computational Systems Biology

Groundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceutical science, and physics solve complex biological problems. Written by leading experts in the field, this practical resource gives detailed descriptions of core subjects, including biological network modeling, analysis, and inference; presents a measured introduction to foundational topics like genomics; and describes state-of-the-art software tools for systems biology. Offers a coordinated integrated systems view of defining and applying computational and mathematical tools and methods to solving problems in systems biology Chapters provide a multidisciplinary approach and range from analysis, modeling, prediction, reasoning, inference, and exploration of biological systems to the implications of computational systems biology on drug design and medicine Helps reduce the gap between mathematics and biology by presenting chapters on mathematical models of biological systems Establishes solutions in computer science, biology, chemistry, and physics by presenting an in-depth description of computational methodologies for systems biology Elements of Computational Systems Biology is intended for academic/industry researchers and scientists in computer science, biology, mathematics, chemistry, physics, biotechnology, and pharmaceutical science. It is also accessible to undergraduate and graduate students in machine learning, data mining, bioinformatics, computational biology, and systems biology courses.

13634.04 RUR

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Young Daniel L. Systems Biology in Drug Discovery and Development

The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

11620.96 RUR

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David J. Balding Handbook of Statistical Systems Biology

Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.

17344.09 RUR

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Robert A. Meyers Systems Biology

Systems biology is a relatively new biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Systems biology is the study of the interconnected aspect of molecular, cellular, tissue, whole animal and ecological processes, and comprises mathematical and mechanistic studies of dynamical, mesoscopic, open, spatiotemporally defined, nonlinear, complex systems that are far from thermodynamic equilibrium.

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Gustavo Caetano-Anollés Evolutionary Genomics and Systems Biology

A comprehensive, authoritative look at an emergent area in post-genomic science, Evolutionary genomics is an up-and-coming, complex field that attempts to explain the biocomplexity of the living world. Evolutionary Genomics and Systems Biology is the first full-length book to blend established and emerging concepts in bioinformatics, evolution, genomics, and structural biology, with the integrative views of network and systems biology. Three key aspects of evolutionary genomics and systems biology are covered in clear detail: the study of genomic history, i.e., understanding organismal evolution at the genomic level; the study of macromolecular complements, which encompasses the evolution of the protein and RNA machinery that propels life; and the evolutionary and dynamic study of wiring diagrams—macromolecular components in interaction—in the context of genomic complements. The book also features: A solid, comprehensive treatment of phylogenomics, the evolution of genomes, and the evolution of biological networks, within the framework of systems biology A special section on RNA biology—translation, evolution of structure, and micro RNA and regulation of gene expression Chapters on the mapping of genotypes to phenotypes, the role of information in biology, protein architecture and biological function, chromosomal rearrangements, and biological networks and disease Contributions by leading authorities on each topic Evolutionary Genomics and Systems Biology is an ideal book for students and professionals in genomics, bioinformatics, evolution, structural biology, complexity, origins of life, systematic biology, and organismal diversity, as well as those individuals interested in aspects of biological sciences as they interface with chemistry, physics, and computer science and engineering.

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Guoan Luo Systems Biology for Traditional Chinese Medicine

The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.

18613.17 RUR

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Gutiérrez Rodrigo Annual Plant Reviews, Plant Systems Biology

Plant Systems Biology is an excellent new addition to the increasingly well-known and respected Annual Plant Reviews. Split into two parts, this title offers the reader: A fundamental conceptual framework for Systems Biology including Network Theory The progress achieved for diverse model organisms: Prokaryotes, C. elegans and Arabidopsis The diverse sources of “omic” information necessary for a systems understanding of plants Insights into the software tools developed for systems biology Interesting case studies regarding applications including nitrogen-use, flowering-time and root development Ecological and evolutionary considerations regarding living systems This volume captures the cutting edge of systems biology research and aims to be an introductory material for undergraduate and graduate students as well as plant and agricultural scientists, molecular biologists, geneticists and microbiologists. It also serves as a foundation in the biological aspects of the field for interested computer scientists. Libraries in all universities and research establishments where biological and agricultural sciences are studied and taught and integrated with Computer Sciences should have copies of this important volume on their shelves.

25067.41 RUR

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Группа авторов Cell Culture Engineering

Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to present expert coverage of topics such as: cell line development for therapeutic protein production; development of a transient gene expression upstream platform; and CHO synthetic biology. They provide readers with everything they need to know about enhancing product and bioprocess attributes using genome-scale models of CHO metabolism; omics data and mammalian systems biotechnology; perfusion culture; and much more. This all-new, up-to-date reference covers all of the important aspects of cell culture engineering, including cell engineering, system biology approaches, and processing technology. It describes the challenges in cell line development and cell engineering, e. g. via gene editing tools like CRISPR/Cas9 and with the aim to engineer glycosylation patterns. Furthermore, it gives an overview about synthetic biology approaches applied to cell culture engineering and elaborates the use of CHO cells as common cell line for protein production. In addition, the book discusses the most important aspects of production processes, including cell culture media, batch, fed-batch, and perfusion processes as well as process analytical technology, quality by design, and scale down models. -Covers key elements of cell culture engineering applied to the production of recombinant proteins for therapeutic use -Focuses on mammalian and animal cells to help highlight synthetic and systems biology approaches to cell culture engineering, exemplified by the widely used CHO cell line -Part of the renowned «Advanced Biotechnology» book series Cell Culture Engineering: Recombinant Protein Production will appeal to biotechnologists, bioengineers, life scientists, chemical engineers, and PhD students in the life sciences.

14100.89 RUR

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Systems Biology and Synthetic Biology: Fu ...

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Pengcheng FU | Professor | Beijing University of Chemical ...

Pengcheng fu currently works at the Life Sciences and Biotechnology, Beijing University of Chemical Technology. Pengcheng does research in Bioengineering, Biosystems Engineering and Chemical ...

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Pengcheng Fu, Phd, is a professor in the Faculty of Chemical Science and Engineering, China University of Petroleum, Beijing. His research interests include: biofuels and bioenergy, metabolic engineering, functional genomics, genome-scale modeling, bioprocess control, metabolomics/metabolite profiling, systems biology, and synthetic biology.

Systems Biology and Synthetic Biology: Fu, Pengcheng ...

Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on ...

Pengcheng Fu (Author of Systems Biology and Synthetic Biology)

Pengcheng Fu is the author of Systems Biology and Synthetic Biology (2.67 avg rating, 3 ratings, 0 reviews, published 2009)

Pengcheng Fu | Beijing University of Chemical Technology ...

Pengcheng Fu, Beijing University of Chemical Technology, Life Sciences and Biotechnology Department, Faculty Member. Studies Systems Biology, Applied microbiology, and Genomics. Dr. Patrick (Pengcheng) Fu is a professor of College of Life Sciences

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Xuzhou - Wikipedia

Xuzhou (徐州), also known as Pengcheng (彭城) in ancient times, is a major city in northwestern Jiangsu province, China. The city, with a recorded population of 8,577,225 at the 2010 census (2,623,066 of which lived in the built-up area), is a national complex transport hub and an important gateway city in East China. Xuzhou is a central city of Huaihai Economic Zone and Xuzhou ...

Professor : Fu Pengcheng_Foreign Expert _Beijing ...

1996.7 ~ 1997.11 Postdoctoral Research Fellow, Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Japan. 1988.8 ~ 1991.1 Control and Instrumentation Engineer, Guangzhou Petrochemical Works, SINOPEC Co. Ltd. China . Achievement . Research Projects

‪Pengcheng Fu‬ - ‪Google Scholar‬

Pengcheng Fu. Lawrence Livermore National Laboratory. Verified email at - Homepage. geomechanics materials soil mechanics rock mechanics hydraulic fracturing. Articles Cited by Co-authors. Title. Sort . Sort by citations Sort by year Sort by title. Cited by. Cited by. Year; An explicitly coupled hydro‐geomechanical model for simulating hydraulic fracturing in arbitrary discrete ...

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Pengcheng Fu Frederick J Ryerson This work aims to address a challenge posed by recent observations of tightly-spaced hydraulic fractures in core samples from the Hydraulic Fracturing Test Site ...

Loop | Pengcheng Fu

Pengcheng (Patrick) Fu received his undergraduate training in chemical engineering at Zhejing University, China in 1982. He obtained his M.S. degree in chemical engineering at Zhejing University in 1988 and his Ph.D. degree in biochemical engineering at University of Sydney, Australia in 1996, respectively. He then performed postdoctoral research in Kyushu Institute ...

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Pengcheng Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO). Pixel circuit, driving method, display panel and display device . Patent number: 10770000 Abstract: A pixel circuit, a driving method, a display panel and a ...

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Pengcheng Fu - YouTube

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Applications include the stimulation of unconventional oil and gas reservoirs, engineered and hydrothermal geothermal systems, and CO 2 sequestration. I am one of the original developers of LLNL’s GEOS code. I am also active in the study of geomaterials using particle-based simulations.

Fu Pengcheng (@Fu_Pengcheng1) | Twitter

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Fußbodenheizung nachrüsten: Das Trockensystem: Vorteil geringe Aufbauhöhe Für eine Warmwasser-Fußbodenheizung zu verlegen, gibt es zwei Systeme: das Trockensystem oder Nasssystem. Das Trockensystem eignet sich insbesondere für Sanierer, weil es auch nachträglich eingebaut werden kann. Durch den speziellen Aufbau kommen Trockenbau-Fußbodenheizungen…

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Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological ...

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Pengcheng Fu. Weill Cornell Medical College Medicine/Endocrinology Papers: Dissociation of a Camptothecin Analog NSC606985 Induced Unconventional ER-Stress and Cell Death in DU145 Prostate Cancer Cells ...

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dblp: Pengcheng Yin

Lili Fu, Pengcheng Yin, Gang Li, Zhifeng Shi, Youzhi Liu, Ji-yi Zhang: Characteristics and Classification of Topological Spatial Relations in 3-D Cadasters. Inf. 9 ( 4 ) : 71 ( 2018 )

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Josef Hormes Nanofabrication Towards Biomedical Applications

This book focuses on the materials, synthetic methods, tools and techniques being developed in the nanoregime towards the life sciences – in particular biology, biotechnology and medicine. Readers from materials science, engineering, chemistry, biology and medical backgrounds will find detailed accounts of the design and synthesis of nanomaterials and the tools and techniques involved in their production for applications in biology, biotechnology and medicine.

25346.5 RUR

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C. U. M. Smith Biology of Sensory Systems

Since publication of the first edition, huge developments have taken place in sensory biology research and new insights have been provided in particular by molecular biology. These show the similarities in the molecular architecture and in the physiology of sensory cells across species and across sensory modality and often indicate a common ancestry dating back over half a billion years. Biology of Sensory Systems has thus been completely revised and takes a molecular, evolutionary and comparative approach, providing an overview of sensory systems in vertebrates, invertebrates and prokaryotes, with a strong focus on human senses. Written by a renowned author with extensive teaching experience, the book covers, in six parts, the general features of sensory systems, the mechanosenses, the chemosenses, the senses which detect electromagnetic radiation, other sensory systems including pain, thermosensitivity and some of the minority senses and, finally, provides an outline and discussion of philosophical implications. New in this edition: Greater emphasis on molecular biology and intracellular mechanisms New chapter on genomics and sensory systems Sections on TRP channels, synaptic transmission, evolution of nervous systems, arachnid mechanosensitive sensilla and photoreceptors, electroreception in the Monotremata, language and the FOXP2 gene, mirror neurons and the molecular biology of pain Updated passages on human olfaction and gustation. Over four hundred illustrations, boxes containing supplementary material and self-assessment questions and a full bibliography at the end of each part make Biology of Sensory Systems essential reading for undergraduate students of biology, zoology, animal physiology, neuroscience, anatomy and physiological psychology. The book is also suitable for postgraduate students in more specialised courses such as vision sciences, optometry, neurophysiology, neuropathology, developmental biology. Praise from the reviews of the first edition: «An excellent advanced undergraduate/postgraduate textbook.» ASLIB BOOK GUIDE «The emphasis on comparative biology and evolution is one of the distinguishing features of this self-contained book. .... this is an informative and thought-provoking text…» TIMES HIGHER EDUCATIONAL SUPPLEMENT

22047.79 RUR

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Группа авторов Synthetic Multivalent Molecules

This book provides basic principles of multivalent interactions found in biological systems as well as an up-to-date and thorough coverage in design concepts, syntheses, and biological activities of multivalent molecules. * Contains practical examples of synthetic multivalent molecules in chemistry, biology, and medicine * Can be used as both a textbook for students and a reference book for libraries and professionals * Includes detailed case studies * Fills a void in current literature through its devotion solely to multivalent molecules

17202.68 RUR

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Группа авторов Plant Biotechnology and Genetics

Focused on basics and processes, this textbook teaches plant biology and agriculture applications with summary and discussion questions in each chapter. Updates each chapter to reflect advances / changes since the first edition, for example: new biotechnology tools and advances, genomics and systems biology, intellectual property issues on DNA and patents, discussion of synthetic biology tools Features autobiographical essays from eminent scientists, providing insight into plant biotechnology and careers Has a companion website with color images from the book and PowerPoint slides Links with author's own website that contains teaching slides and graphics for professors and students:

11085.47 RUR

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Группа авторов Multivalency

Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book. Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology.

11465.11 RUR

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Thomas Müller J.J. Functional Organic Materials

This timely overview of the syntheses for functional pi-systems focuses on target molecules that have shown interesting properties as materials or models in physics, biology and chemistry. The unique concept allows readers to select the right synthetic strategy for success, making it invaluable for a number of industrial applications. A «must have» for everyone working in this new and rapidly expanding field.

43738.72 RUR

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Markus Schmidt Synthetic Biology. Industrial and Environmental Applications

This is the only book to focus on industrial and environmental applications of synthetic biology, covering 17 of the most promising uses in the areas of biofuel, bioremediation and biomaterials. The contributions are written by experts from academia, non-profit organizations and industry, outlining not only the scientific basics but also the economic, environmental and ethical impact of the new technologies. This makes it not only suitable as supplementary material for students but also the perfect companion for policy makers and funding agencies, if they are to make informed decisions about synthetic biology. Largely coordinated by Markus Schmidt, a policy adviser, and the only European to testify in front of the bioethics commission of the Obama administration.

2557.53 RUR

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Jens Petter Nielsen Synthetic Biology

A review of the interdisciplinary field of synthetic biology, from genome design to spatial engineering Written by an international panel of experts, Synthetic Biology draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy. Filled with the most recent research, compelling discussions, and unique perspectives, Synthetic Biology offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research. Advanced Biotechnology Biotechnology is a broad, interdisciplinary field of science, combining biological sciences and relevant engineering disciplines, that is becoming increasingly important as it benefits the environment and society. Recent years have seen substantial advances in all areas of biotechnology, resulting in the emergence of brand new fields. To reflect this progress, Sang Yup Lee (KAIST, South Korea), Jens Nielsen (Chalmers University, Sweden), and Gregory Stephanopoulos (MIT, USA) have joined forces as the editors of a new Wiley-VCH book series. Advanced Biotechnology will cover all pertinent aspects of the field and each volume will be prepared by eminent scientists who are experts on the topic in question.

16928.17 RUR

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Gilles Gasser Inorganic Chemical Biology. Principles, Techniques and Applications

Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.

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